Introduction to TGA, STA and Evolved Gas Analysis in Pharmaceutical Characterization

Understanding composition, Thermal StabilityA material is thermally stable if it does not decompose under the influence of temperature. One way to determine the thermal stability of a substance is to use a TGA (thermogravimetric analyzer). thermal stability and Decomposition reactionA decomposition reaction is a thermally induced reaction of a chemical compound forming solid and/or gaseous products. decomposition behavior is essential throughout pharmaceutical development and quality control. Thermogravimetric Analysis (TGA) detects changes in sample mass, revealing valuable information about moisture, volatile components, degradation processes and material composition.

In Part 3 of our Pharmaceutical Characterization Webinar Series, we introduce the fundamentals of TGA, Simultaneous Thermal Analysis (STA) and Evolved Gas Analysis (EGA). Learn how the instruments work, how to develop reliable measurement methods and how to interpret mass-loss and gas-analysis signals.

Application examples will demonstrate how TGA and EGA support the characterization of APIs, excipients and pharmaceutical formulations. The session also prepares participants for the following webinar, which will explore practical applications and real-world case studies in greater detail.

Topics Covered

• TGA and EGA across the pharmaceutical characterization value chain
• Instrument design, measurement principles and atmosphere control
• Sample preparation and method development
• Coupling techniques: TGA-FTIR and TGA-MS
• Moisture, volatile content and thermal Decomposition reactionA decomposition reaction is a thermally induced reaction of a chemical compound forming solid and/or gaseous products. decomposition
• Residual mass, composition analysis and DTG evaluation
• Correlation of mass-loss steps with evolved gases
• API and excipient characterization
• Software compliance, SmartMode and ExpertMode
• AutoEvaluation, c-DTA^®, Identify and Proteus^® Search Engine
• LIMS support
   

Join the webinar and discover how TGA, STA and EGA provide deeper insights into pharmaceutical materials, their composition and Thermal StabilityA material is thermally stable if it does not decompose under the influence of temperature. One way to determine the thermal stability of a substance is to use a TGA (thermogravimetric analyzer). thermal stability.