DSC 204 F1 Nevio

…by means of the DSC 204 F1 Nevio, the premium differential scanning calorimeter for research and development, material characterization and contract testing.

The instrument serves for the investigation of:

Melting Temperatures and EnthalpiesThe enthalpy of fusion of a substance, also known as latent heat, is a measure of the energy input, typically heat, which is necessary to convert a substance from solid to liquid state. The melting point of a substance is the temperature at which it changes state from solid (crystalline) to liquid (isotropic melt).Melting temperatures and enthalpies of fusion
PolymorphismPolymorphism is the ability of a solid material to form different crystalline structures (synonyms: forms, modifications).Polymorphism (ability of a solid substance to exist in multiple forms or crystal structures)
CrystallizationCrystallization is the physical process of hardening during the formation and growth of crystals. During this process, heat of crystallization is released.Crystallization temperatures and enthalpies
Glass Transition TemperatureThe glass transition is one of the most important properties of amorphous and semi-crystalline materials, e.g., inorganic glasses, amorphous metals, polymers, pharmaceuticals and food ingredients, etc., and describes the temperature region where the mechanical properties of the materials change from hard and brittle to more soft, deformable or rubbery.Glass transitions (characteristic for amorphous areas or amorphous substances)
Solid-solid interactions (e.g., between ingredients in a physical mixture)
Phase diagrams
Eutectic PurityA eutectic system is a homogeneous mixture of 2 components that melts and solidifies like a pure substance.Eutectic purity
Solid-fat content (SFC)
Reaction temperatures and enthalpies
Specific Heat Capacity (cp)Heat capacity is a material-specific physical quantity, determined by the amount of heat supplied to specimen, divided by the resulting temperature increase. The specific heat capacity is related to a unit mass of the specimen.Specific heat capacity (c_p)
Curing (Crosslinking Reactions)Literally translated, the term “crosslinking“ means “cross networking”. In the chemical context, it is used for reactions in which molecules are linked together by introducing covalent bonds and forming three-dimensional networks.Cross-linking reactions (Curing (Crosslinking Reactions)Literally translated, the term “crosslinking“ means “cross networking”. In the chemical context, it is used for reactions in which molecules are linked together by introducing covalent bonds and forming three-dimensional networks.curing)
OxidationOxidation can describe different processes in the context of thermal analysis.Oxidation-induction time and temperature (Oxidative-Induction Time (OIT) and Oxidative-Onset Temperature (OOT)Oxidative Induction Time (isothermal OIT) is a relative measure of the resistance of a (stabilized) material to oxidative decomposition. Oxidative-Induction Temperature (dynamic OIT) or Oxidative-Onset Temperature (OOT) is a relative measure of the resistance of a (stabilized) material to oxidative decomposition.OIT (IsothermalTests at controlled and constant temperature are called isothermal.isothermal), Oxidative-Induction Time (OIT) and Oxidative-Onset Temperature (OOT)Oxidative Induction Time (isothermal OIT) is a relative measure of the resistance of a (stabilized) material to oxidative decomposition. Oxidative-Induction Temperature (dynamic OIT) or Oxidative-Onset Temperature (OOT) is a relative measure of the resistance of a (stabilized) material to oxidative decomposition.OIT (dynamic), Oxidative-Induction Time (OIT) and Oxidative-Onset Temperature (OOT)Oxidative Induction Time (isothermal OIT) is a relative measure of the resistance of a (stabilized) material to oxidative decomposition. Oxidative-Induction Temperature (dynamic OIT) or Oxidative-Onset Temperature (OOT) is a relative measure of the resistance of a (stabilized) material to oxidative decomposition.OOT)

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Features of the DSC 204 `F1` `Nevio`:

Software which actively supports you – AutoEvaluation and Identify

AutoEvaluation is the first truly self-acting software feature in thermal analysis. Intelligent algorithms are able to detect and evaluate thermal effects without any user intervention.
Identify is software for curve recognition and interpretation via database comparison. It can manage measurements (also those of a customer’s own), literature data and classes. Numerous libraries are already included, amongst them also one containing data related to the fields of pharmacy, food and cosmetics.

All set for the future – various sensor types

The DSC 204 F1 Nevio can be equipped with different sensors to adapt the instrument to different application needs.

Excellent sensitivity and high resolution

With a value of more than 160 mW/K, the DSC 204 F1 Nevio with _t sensor exhibits the highest indium response ratio on the market. This height-to-width ratio of an indium melting peak is an ideal criterion for describing the sensor performance.

Automatic sample tray identification

The instrument can be fitted with an automatic sample changer (ASC, optional) for measuring up to 192 samples plus up to 12 calibration materials or empty pans. If a new sample tray is inserted, the system recognizes the tray and its content automatically via an imprinted 2-D code.
Additionally, the optional piercing device perforates the lids of aluminum pans shortly before a given measurement starts.

Measuring methods independent of instrument

Measurement methods (which can comprise not only temperature programs but also evaluation of the resulting curve) can be used on each device of the same type and comparable configuration. This is particularly advantageous if several DSCs of the Nevio line (DSC 204 F1 or DSC 214 instruments) are installed in the lab.

Efficient and cost-effective cooling

In pharmacy, cosmetics and food, most DSC instruments are equipped with a mechanical cooling system (intracooler). However, if very low start temperatures are required, a liquid nitrogen cooling device can be simultaneously connected to the DSC 204 F1 Nevio. In this case, the LN₂ cooling will only be activated at temperatures below -85°C, which reduces the liquid nitrogen consumption considerably.

The Proteus^® Protect software meets the requirements of 21 CFR Part 11.