The book contains eight chapters on more than 260 pages about:
- Thermal analysis methods (DSC, TGA, STA and Gas Analysis)
- Characterization of amorphous and crystalline phases
- Thermal stability
- Oxidative stability
- Storage conditions and shelf life
- Polymorphism and
This application book uses a variety of specific application examples to illustrate how the corresponding experiments are to be carried out and what conclusions can be drawn from the results.
Please read a book review by Mr. Jascha Schinke, PhD student at the University of Innsbruck:
“The book “Thermal Analysis in the Pharmaceutical Field”, written by Dr. Gabriele Kaiser and Claire Strasser and published by NETZSCH, is a book about the possible applications of thermal analysis in the pharmaceutical area.
On over 262 pages, the use of thermoanalytical methods in the field of pharmacy is illustrated. Thereby, the authors describe at first the theory of different thermal methods and then the utilization of them in six different pharmaceutical application fields. In the end, they demonstrate the usefulness of thermal methods in relation to compatibility screenings in drug design.
The book is divided into eight chapters. The subdivision of the chapters can be summarized in three thematic blocks: theory, studies and screenings. The theory block describes the background of Differential Scanning Calorimetry (DSC), Thermogravimetry (TGA), Simultaneous Analysis (STA), Evolved Gas Analysis and Thermomechanical Analysis (TMA). Further, some NETZSCH software programs are illustrated.
In the second block, the authors demonstrate the use of the thermal methods to determine, for example, the purity and polymorphic behavior of compounds. The studies are summarized and described with examples. Furthermore, not only active ingredients but also excipients, which play an important role in the pharmaceutical field, are considered. Important concepts such as phase diagrams and relative humidity are also described and explained with examples in appendices.
The last part describes the use of DSC and TGA for determining the compatibility of dosage forms. It is shown how thermal methods can quickly reveal whether an active ingredient and an excipient can interact.
To sum up – each chapter first addresses important points that are significant for the thermal analysis of pharmaceuticals and is then rounded off with good examples. The authors thereby manage to guide the reader through the topics.
The book “Thermal Analysis in the Pharmaceutical Field” provides a good summary of applications of thermal analysis in pharmacy. The chapters were chosen sensibly, and the selected examples show direct application to issues in pharmacy. In my opinion, the book is suitable for beginners just getting into thermal analysis as well as for advanced experts, since the subject area of thermal analysis has been summarized very clearly. It was a great pleasure for me to read this book. I will be happy to use it as a reference in the future.”
Jascha Schinke, thank you very much for this review!