Thermal Analysis and Rheology for Pharmaceutical Applications
Thermal Analysis provides powerful analytical methods for research, development and quality control of active pharmaceutical ingredients (APIs), excipients and formulations. This implies the determination of their physicochemical properties such as Melting Temperatures and EnthalpiesThe enthalpy of fusion of a substance, also known as latent heat, is a measure of the energy input, typically heat, which is necessary to convert a substance from solid to liquid state. The melting point of a substance is the temperature at which it changes state from solid (crystalline) to liquid (isotropic melt).melting point, Glass Transition TemperatureThe glass transition is one of the most important properties of amorphous and semi-crystalline materials, e.g., inorganic glasses, amorphous metals, polymers, pharmaceuticals and food ingredients, etc., and describes the temperature region where the mechanical properties of the materials change from hard and brittle to more soft, deformable or rubbery.glass transition temperature and heat of fusion, compatibility studies to find suitable API-excipient combinations, purity assessments (eutectic purity) and characterization of polymorphic forms.
Rheology perfectly complements the analytical equipment of your laboratory and allows for the specification of a suitable viscosity for different pharmaceutical products, assessment of flow limits of ointments and creams, predictions of storage stability by means of oscillation measurements as well as the determination of mechanical characteristics of soft gels.
The following blog article will give you an idea about testing possibilities
- 5 reasons why to use DSC and TGA for testing pharmaceuticals
- How can rheology help in the development of a treatment for COVID-19
- The Importance of Purity Determination of Pharmaceuticals
- Monitoring the Polymorphism of Paracetamol by Means of DSC
- Drug excipient compatibility check during the development
- Rheology of Topical Treatments
- Rheology: De-stressing the test of time
- Reliable Characterization of Pharmaceuticals Using Thermal Analysis