Practical Applications of TGA and EGA in Pharmaceutical Characterization

Building on the fundamentals introduced in the previous session, this webinar shows how TGA and EGA can help solve real-world challenges in pharmaceutical development, manufacturing and quality control.

In Part 4 of our Pharmaceutical Characterization Webinar Series, practical examples and case studies demonstrate how these techniques support the characterization of APIs, excipients and finished formulations. Learn how to assess Thermal StabilityA material is thermally stable if it does not decompose under the influence of temperature. One way to determine the thermal stability of a substance is to use a TGA (thermogravimetric analyzer). thermal stability and compatibility, identify moisture, residual solvents and Decomposition reactionA decomposition reaction is a thermally induced reaction of a chemical compound forming solid and/or gaseous products. decomposition products, compare batches and investigate the effects of processes such as drying and milling.

The session also introduces kinetic analysis and shelf-life prediction. Discover how thermal data and Kinetics Neo can be used to evaluate degradation behavior, optimize processes and forecast long-term product stability.

Topics Covered

• Composition, residue and batch-to-batch evaluation
• Thermal stability and Drug-Excipient CompatibilityMedicine is not a single active ingredient but a mixture of the active ingredient with different excipients. In a tablet for example, excipients are used to improve the appearance and taste of the final product, to prevent the tablet from sticking to the punching tool, or to help it dissolve as soon as it is wet, etc.drug-excipient compatibility
• Identification of Decomposition reactionA decomposition reaction is a thermally induced reaction of a chemical compound forming solid and/or gaseous products. decomposition products
• Practical TGA-FTIR and TGA-MS examples
• Effects of drying and milling processes
• Introduction to kinetic analysis
• Kinetics Neo software workflow
• Lifetime and shelf-life prediction
• Process optimization and stability forecasting
• SmartMode, ExpertMode and AutoEvaluation
• c-DTA^®, Identify and Proteus^® Search Engine
• LIMS support and advanced prediction tools
   

Join the webinar and discover how TGA, EGA and kinetic analysis can support confident decisions throughout pharmaceutical development and manufacturing.